Treatment of metastatic and/or unresectable GIST: Bayer has submitted a “New Drug Application (NDA)” to the FDA for Regorafenib.
End of August 2012, Bayer HealthCare has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for its oral multi-kinase inhibitor Regorafenib for the treatment of metastatic and/or unresectable GIST (Gastrointestinal Stromal Tumours) in patients whose disease has progressed despite prior treatment with other kinase inhibitors. Usually these prior therapy options are Imatinib (Glivec®) as a first-line-treatment and Sunitinib (Sutent®) as a second-line-treatment.
European Commission grants marketing authorisation for Pazopanib (Votrient®) in the treatment of certain advanced soft tissue sarcoma subtypes
GlaxoSmithKline (GSK) announced on the 7th of August 2012 that the European Commission has granted Pazopanib marketing authorisation for the treatment of patients with advanced soft tissue sarcoma (aSTS) who have received prior chemotherapy or have progressed within 12 months after (neo) adjuvant therapy. Efficacy and safety has only been established in certain STS histological tumour subtypes.
SPAEN is delighted to provide a comprehensive report of the ASCO 2012 medical highlights in GIST and Sarcomas from Dr Axel Le Cesne, Gustave Roussy Institute, Villejuif (France). Sarcomas and GIST were presented at 5 plenary and parallel sessions. These were rich in terms of innovation and therapeutic concepts, reporting study results that may have an impact on our daily practice, whether in GIST or sarcomas.
Dr Bielak's summary of the state of osteosarcoma treatment presents current evidence on the best way to manage osteosarcoma patients and looks at what has to be done to improve prognosis in this disease, where survival rates have not changed since the early 1980's.
EORTC is currently conducting A phase III randomized study of preoperative radiotherapy plus surgery versus surgery alone for patients with Retroperitoneal sarcomas (RPS) - STRASS. SPAEN has developed a leaflet/article explaining the STRASS study in non-technical terms with the aim to help patients and carers understand what the study might be able to offer them. This summary is not part of the study information and is not intended to replace any of the study information which is part of the informed consent process.
The annual British Sarcoma Group Conference 2012 - Personalising Treatment and Care took place in Oxfordshire from 29 February - 2 March 2012. It is the main educational and networking event for all UK healthcare professionals and allied healthcare professionals treating patients with sarcoma. It was attended by almost 200 delegates representing a wide range of disciplines including oncology, surgery, pathology, research, specialist nursing, and physiotherapy, alongside representatives from the pharmaceutical industry, patient organisations and charities.
Sarcomas are rare malignant tumors, with an overall incidence of 6/105/year. Bone and soft tissue connective tissue tumours encompass more than 50 different rare histotypes and more than 150 different molecular subtypes. The incidence of individual rare sarcomas subtypes is often less than 0.5/105/year. Given the rarity of sarcomas as a group, but even more as individual entities, few prospective clinical trials testing local or systemic treatments have been performed in specific subtypes of sarcomas. Clinical trials in specific histological and molecular subtypes of sarcoma can only be performed through integrated clinical networks, centres of clinical excellence, supported by translational analysis.
The National Institutes of Health (NIH) and its branch the National Institute of Child Health and Human Development have announced an exciting initiative for those affected by pediatric GIST, Carney Triad, GIST from Carney-Stratakis syndrome, or other wildtype GIST: NIH Clinic for Pediatric and Wildtype GIST. In January 2012 the pre-clinic meeting of the 8th Pediatric and Wildtype GIST Clinic at NIH took place and we are delighted to publish a report of a representative of GIST Support International (GSI) who has attended the meeting. Read more.
The Liddy Shriver Sarcoma Initiative publishes accurate and timely information about the diagnosis and treatment of sarcomas in ESUN, its online, peer-reviewed newsletter. Recently they have published the ESUN Guide for the Newly Diagnosed. The ESUN Sarcoma Guides have been reviewed by sarcoma experts and published as eBooks for easy access on-the-go. The books can be saved and printed for individual use.